As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 610-97-9 name is Methyl 2-iodobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 610-97-9
Example 1Tert-Butoxy-[4-(4-methoxy-3, 5-dimethyl -phenyl)-2-methyl-1-oxo-1,2-dihydro-isoquinolin-3-yl]-acetic acidStep A Preparation of 2-(3-Hydroxy-prop-1-ynyl)-benzoic acid methyl ester:[00131] To a suspension of compound 1 (88.0 g, 335.9 mmol), compound 2 (28.3 g, 503.8 mmol), copper iodide (1 .2 g, 6.7 mmol), Pd(PPh3) CI2 (7.0 g, 10.0 mmol) and Et3N (triethylamine) (68.0 g, 671 .8 mmol) in acetonitrile (1 L) was bubbled N2 for 20 min. The resultant mixture was stirred at reflux under N2 for 3 hr. The reaction mixture was filtered and the filtrate was concentrated to dryness. The residue was purified by chromatography to afford title product. (m=58.8 g, yield=92.0%). 1 HNMR: (400MHz, d6-DMSO) delta 2.48 (t, J=6.2 Hz, 1 H), 3.88 (s, 3 H), 4.52 (d, J=5.6 Hz, 2 H), 7.32 (t, J=7.6Hz, 1 H), 7.41 (t, J=7.6Hz, 1 H), 7.51 (d, J=7.6Hz, 1 H), 7.90 (d, J=7.2Hz, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-iodobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE LLC; DE LA ROSA, Martha Alicia; HAYDAR, Simon, N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann; WO2012/102985; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com