A common heterocyclic compound, 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, molecular formula is C8H7IO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1878-94-0.
The reaction mixture of N-deacetylthiocolchicine (24 mg, 0.064 mmol), 4-iodophenoxyacetic acid (41 mg, 0.15 mmol), EDCI (29 mg), DMAP (2 mg, 0.2 mmol) and dichloromethane (3 ml) was stirred at room temperature for 20 h. Then dichloromethane (20 ml) was added. Organic layer was washed with H2O, 5% Na2CO3 and brine, and then dried over MgSO4. After the solvent was removed under vacuum, the residue was separated by column chromatography (eluent: ethyl acetate and petroleum ether) to afford 35 mg N-Deacetyl-N-(4-iodophenoxyacetyl)thiocolchicine. [0571] The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz).
The synthetic route of 2-(4-Iodophenoxy)acetic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yang, Li-Xi; US2004/204370; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com