608-28-6, A common heterocyclic compound, 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, molecular formula is C8H9I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
One 250ml flask was charged with 4-phenyl imidazole (7.08g, 49.12mmole), 2- iodo-m-xylene(9.5g, 40.93mmole), copper (5.721g, 90.046mmole); 18-crown-6 (1.08Ig, 4.09 mmole), K2CO3 (21.49g, 155.53 mmole) and tetrahydronaphthalene (90ml). Reaction was heated to 180 C for 68hrs. Reaction mixture was then filtered through Celite and the filtrate was concentrated to dryness. The residue was subjected to kugelrohr distillation and 4g of ligand was obtained.(39%).
The synthetic route of 608-28-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; WO2006/121811; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com