Extended knowledge of 1,2-Difluoro-4-iodobenzene

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Difluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

64248-58-4, A common compound: 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 40; 4- {6-[2-(3,4-Difluorophenyl)-l -ethynyl]-3-pyridazinyl}piperazino-2(trifluoromethyl)- phenylmethanone; Prepared by Sonogashira coupling reaction of Intermediate 6 with l,2-difluoro-4- iodobenzene in a mixture of triethylamine and DMSO to give the product as a white solid; IR (KBr) 2856, 2220, 1655, 1510, 1265, 1147, 1009 cm”1; 1H NMR (300 MHz, CDCl3) delta 3.32- 3.36 (m, 2H), 3.72-4.10 (m, 6H), 6.88 (d, J= 9.3 Hz, IH), 7.12-7.16 (m IH), 7.28-7.65 (m, 6H), 7.73 (d, J= 9.3 Hz, IH) ; ESI-MS (m/z) 472.62 (M)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Difluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; WO2008/62276; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com