627-32-7, Name is 3-Iodo-1-propanol, 627-32-7, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
General procedure: 4.2.1.7 10-(3-Hydroxypropoxy)-3,9-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-2-ol (16) Yield 76%; reddish-brown solid, mp 73-78 C; 1H NMR (CDCl3, 500 MHz) 6.87-6.80 (m, 3H), 6.60 (s, 1H), 4.22 (d, J = 15.7 Hz, 1H), 4.16 (td, J = 6.1, 1.5 Hz, 2H), 3.91-3.84 (m, 8H), 3.52 (d, J = 15.4 Hz, 2H), 3.27-3.10 (m, 3H), 2.80 (dd, J = 15.7, 11.6 Hz, 1H), 2.68-2.61 (m, 2H), 2.07 (quint, J = 5.8 Hz, 2H); 13C NMR (CDCl3, 125 MHz) delta 149.4, 145.4, 145.1, 143.9, 130.5, 128.8, 128.4, 126.1, 124.1, 112.5, 111.3, 110.6, 67.5, 61.0, 60.3, 59.2, 55.9, 54.0, 51.6, 36.3, 32.1, 29.2; HRMS (ESI) m/z calcd for C22H27NO5 [M+H]+, 386.1884, found 386.1897.
Statistics shows that 3-Iodo-1-propanol is playing an increasingly important role. we look forward to future research findings about 627-32-7.
Reference:
Article; Gadhiya, Satishkumar; Madapa, Sudharshan; Kurtzman, Thomas; Alberts, Ian L.; Ramsey, Steven; Pillarsetty, Nagavara-Kishore; Kalidindi, Teja; Harding, Wayne W.; Bioorganic and Medicinal Chemistry; vol. 24; 9; (2016); p. 2060 – 2071;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com