The synthetic route of 3-(4-Iodophenyl)propanoic acid has been constantly updated, and we look forward to future research findings.
1643-29-4, A common heterocyclic compound, 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid, molecular formula is C9H9IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 16; Commercially available 3-(4-iodophenyl)propionic acid (200 mg, 0.72 mmol) was combined with phenyl boronic acid (177 mg, 1.45 mmol), catalytic tetrakis-(triphenylphosphine)- palladium (20 mg), and saturated aqueous sodium bicarbonate (IM5 1.45 mL, 1.45 mmol) in (1:1) dioxane-ethanol (5 mL). The reaction mixture was heated at 100 0C overnight, cooled to room temperature, filtered, and concentrated in vacuo. The residue was purified via preparative RPHPLC to give the biaryl propionic acid intermediate, which is defined as Compound 15 in Scheme 5. This intermediate acid was converted into EXAMPLE 16 in a manner similar to the Examples above. The compound was purified via preparative RPHPLC to give the desired product. 1H KfMR (CD3OD, 500 MHz) delta 7.68-7.62 (m, 4H), 7.51-7.38 (m, 5H), 6.93 (s5 IH), 3.12 (t, 2H), 2.93 (t, 2H), 2.80 (q, 2H)5 2.66 (s, IH), 1.33 (t, 3H); LCMS m/z 378 (M-I).
The synthetic route of 3-(4-Iodophenyl)propanoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2007/120575; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com