In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1878-69-9 as follows. 1878-69-9
2- (3-LODOPHENYL) ETHANOL; A solution of borane (1 M, THF, 2.5 eq. , 38.2 mL) was added dropwise to a stirred solution of (3-iodophenyl) acetic acid (4.0 g) in THF (100 mL) cooled to 0 OC. The resulting mixture was stirred at 0 oC for 1H then warmed to room temperature and stirred for a further 3 h. The mixture was poured into aqueous ammonium chloride solution and extracted with ethyl acetate. The combined organic phases were washed with brine, dried (sodium sulfate) and concentrated. The crude was purified by column chromatography (SPE cartridge, SIO2), using cyclohexane-ethyl acetate (70: 30) as eluent to afford the title compound (3.5 g, 92 % yield). 1H-NMR (400 MHz, CDC . S) 5 (ppm): 7.5-7 (m 5H), 4.0 (m, 2H), 2.9 (m, 2H).
According to the analysis of related databases, 1878-69-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/14552; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com