A common heterocyclic compound, 39998-81-7, name is 2-Fluoro-4-iodo-1-methylbenzene, molecular formula is C7H6FI, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 39998-81-7.
2-Fluoro-4-iodotoluene (2.83 g, 12 mmol) was added to a 250 mL round bottom flask and dissolved in carbon tetrachloride (120 mL).NBS (2.24 g, 12.6 mmol) and BPO (0.06 g, 0.24 mmol) were added to the solution under stirring, and the reaction system was heated to reflux for 9 h under nitrogen protection.After the reaction is completed, it is cooled to room temperature, and the reaction solution is evaporated under reduced pressure to remove the solvent.The crude product was purified by column chromatography (eluting with petroleum ether) to give a white solid (2.16 g, 57%).
The synthetic route of 2-Fluoro-4-iodo-1-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, YINGJUN; ZHANG, JIANCUN; WANG, XIAOJUN; LIN, RUNFENG; CAO, SHENGTIAN; WANG, ZHAOHE; LI, JING; (226 pag.)TWI607995; (2017); B;,
Iodide – Wikipedia,
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