A common heterocyclic compound, 2265-93-2, name is 2,4-Difluoroiodobenzene, molecular formula is C6H3F2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2265-93-2.
[0255] 2-Prop-2-ynyl-2,3-dihydro-isoindol-l-one (50.0mg, 0.29mmol) was dissolved in triethylamine (2mL). To this was added Pd(PPh3)4 (13mg, 0.012mmol), Cul (6.7mg, 0.035mmol) and 2,4-difluoro-l-iodo-benzene (52.0uL, 0.438mmol) and the reaction was allowed to stir overnight. The solvent was evaporated and the residue was purified by prep. TLC (30% EtOAc/Hexanes) to afford the title compound (20.0mg, 24%) as a brown oil. XH NMR (300 MHz, CDC13): 5 7.90 (d, 1H), 7.45 (m, 4H), 6.84 (t, 2H), 4.72 (s, 2H), 4.59 (s, 2H).
The synthetic route of 2,4-Difluoroiodobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com