64248-58-4, A common heterocyclic compound, 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, molecular formula is C6H3F2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of Pd(OAc)2 (11.2 mg, 0.05 mmol) and Ph3As (67.5 mg, 0.22 mmol) in dry DMF (3 mL) was stirred in a Schlenk flask under nitrogen atmosphere at 65 C for 15 min to form the catalyst complex. Then, aryl iodide (3.00 mmol), compound 5 (437 mg, 1.00 mmol), Et3N (708 mg, 7.00 mmol), and HCOOH (0.226 mL, 6.00 mmol) were added. The mixture was heated to 65 C for 24-48 h. After cooling to room temperature, brine (50 mL) was added, and the mixture was extracted with AcOEt. The aqueous layer was dried over MgSO4, filtered, and concentrated. The residue was purified by column chromatography or flash chromatography.
The synthetic route of 64248-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Albayrak, Fatma; Gunkara, Omer Tahir; Ersoy, Elif Basak; Ocal, Nuket; Kaufmann, Dieter E.; Arkivoc; vol. 2017; 5; (2017); p. 244 – 256;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com