3032-81-3, These common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 2-Phenylimidazo[1,2-a]pyrazine 2 (1.0 mmol) was introducedinto a 10 mL vial with (hetero)arylhalide (2.0 mmol), palladiumacetate (0.04 mmol), tricyclohexylphosphine tetrafluoroborate(0.08 mmol), pivalic acid (0.6 mmol) and potassium carbonate(3.0 mmol) in N,N-dimethylacetamide (4 mL). The vial was purgedwith argon for 10 min and then sealed. The mixture was heated at100 C for 18e40 h and then it was cooled to room temperature.Water was added and the aqueous layer was extracted with ethylacetate (2 x 10 mL). The combined organic extracts were washedwith brine and water, dried over sodium sulfate, filtered, concentratedin vacuo and purified by silica gel column chromatography.Trituration with diisopropylic ether afforded the compounds 4aeg.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3032-81-3.
Reference:
Article; Marchand, Pascal; Bazin, Marc-Antoine; Pagniez, Fabrice; Riviere, Guillaume; Bodero, Lizeth; Marhadour, Sophie; Nourrisson, Marie-Renee; Picot, Carine; Ruchaud, Sandrine; Bach, Stephane; Baratte, Blandine; Sauvain, Michel; Pareja, Denis Castillo; Vaisberg, Abraham J.; Le Pape, Patrice; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 381 – 395;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com