19230-28-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19230-28-5 name is 1,3-Dichloro-2-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under an argon atmosphere,2- [3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) biphenyl-5-yl] -4,6- diphenyl- 1,3,5-triazine 2.0 g, 3.9 mmol),2,6-Dichloro-1-iodobenzene (1.2 g, 4.3 mmol),And bis (triphenylphosphine) palladium dichloride(55 mg, 78 mumol)Was suspended in THF (39 mL)To this was added 3 M potassium carbonate aqueous solution (2.6 mL).The mixture was stirred at 80 C. for 30 hours and then allowed to cool to room temperature. Water (30 mL) and methanol (30 mL) were added to the reaction solution, and the resulting precipitate was separated by filtration and washed with water, methanol and hexane.By recrystallizing the obtained solid from toluene,A white solid (1.3 g, 2.5 mmol, 64%) of the intermediate 2- (2 ‘, 6’-dichloro-5-phenylbiphenyl-3-yl) -4,6- diphenyl- ) Was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dichloro-2-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; SHONO, TOMOHIRO; UCHIDA, NAOKI; NOMURA, KEISUKE; HATTORI, KAZUKI; (90 pag.)JP2018/95562; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com