3032-81-3, Adding a certain compound to certain chemical reactions, such as: 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3032-81-3.
To a solution of 3,5-dichloro iodobenzene (1.8 g, 6.6 mmol) in diethyl ether (20 ml) cooled to -78¡ã C. is added n-BuLi (2.8 ml of a 2.5 M solution in hexane, 6.8 mmol). The reaction mixture is stirred at -78¡ã C. for 10 min, allowed to warm to 25¡ã C. and added in three portions to a solution of N-t-butoxycarbonyl-3-ketopiperidine (598 mg, 3.01 mmol) in diethyl ether (10 ml) cooled to 0¡ã C. The reaction mixture is stirred at 25¡ã C. for 30 min. The reaction mixture is diluted with ethyl acetate, washed with 1 N KHSO4, water and brine, dried over sodium sulfate and concentrated in vacuo. The crude product is purified by flash chromatography (silica gel, 30percent to 50percent ethyl acetate in hexane) to give N-t-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-hydroxy piperidine (150 mg).
According to the analysis of related databases, 3032-81-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nantermet, Philippe G.; Barrow, James C.; Selnick, Harold G.; US2001/44454; (2001); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com