Hirner, Joshua J. et al. published their research in Journal of the American Chemical Society in 2014 | CAS: 207115-22-8

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C閳ユ彂 bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 207115-22-8

Alkoxyboration: Ring-Closing Addition of B-O 锜?Bonds across Alkynes was written by Hirner, Joshua J.;Faizi, Darius J.;Blum, Suzanne A.. And the article was included in Journal of the American Chemical Society in 2014.SDS of cas: 207115-22-8 This article mentions the following:

For nearly 70 years, the addition of boron-X 锜?bonds to carbon-carbon multiple bonds has been employed in the preparation of organoboron reagents. However, the significantly higher strength of boron-oxygen bonds has thus far precluded their activation for addition, preventing a direct route to access a potentially valuable class of oxygen-containing organoboron reagents for divergent synthesis. Authors herein report the realization of an alkoxyboration reaction, the addition of boron-oxygen 锜?bonds to alkynes. Functionalized O-heterocyclic boronic acid derivatives are produced using this transformation, which is mild and exhibits broad functional group compatibility. The results demonstrate activation of this boron-O 锜?bond using a gold catalysis strategy that is fundamentally different from that used previously for other boron addition reactions. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8SDS of cas: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C閳ユ彂 bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Siyang, Hai Xiao et al. published their research in Organic Letters in 2016 | CAS: 877264-43-2

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Related Products of 877264-43-2

Correction to “Lewis Acid Catalyzed Tandem Polycyclization of Internal Alkynols and Vinyl Azides” [Erratum to document cited in CA163:686744] was written by Siyang, Hai Xiao;Ji, Xiao Yue;Wu, Xu Rui;Wu, Xin Yan;Liu, Pei Nian. And the article was included in Organic Letters in 2016.Related Products of 877264-43-2 This article mentions the following:

In the supporting information an incorrect X-ray structure and CIF file caused misinterpretation of the structures of 3av;The correction is given. The Abstract/TOC graphic and the graphics of Tables 1 and 2, Schemes 1 and 2, and Figure 2 are incorrect; they have been replaced with the correct information. Page 5221, right column, last paragraph, line 13 does not contain the correct information; The correct information has now been given. Page 5222, right column, lines 12-21 do not have the correct information; The information has been corrected References 16 and 17 are incorrect; The correct references have been given. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Related Products of 877264-43-2).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Related Products of 877264-43-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lim, Chae Jo et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 10297-05-9

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C4H8ClI

Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists was written by Lim, Chae Jo;Kim, Nakjeong;Lee, Eun Kyoung;Lee, Byung Ho;Oh, Kwang-Seok;Yoo, Sung-eun;Yi, Kyu Yang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Electric Literature of C4H8ClI This article mentions the following:

Compounds containing 2-arybenzimidazole ring systems linked to arylpiperidines were synthesized and evaluated as MCH-R1 antagonists. The results of structure-activity relationship studies led to the identification of compound I as a potent MCH-R1 antagonist (IC50 = 1 nM). This compound also has good metabolic stability, and favorable pharmacokinetic and brain penetration properties. However I was found to be potent inhibitor of the hERG potassium channel. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Electric Literature of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Maity, Pintu et al. published their research in Organic Chemistry Frontiers in 2018 | CAS: 5460-32-2

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 5460-32-2

Copper catalyzed cyanation through C=C bond cleavage of gem-aryl dibromide followed by second cyanation of iodoarene by a released CN unit was written by Maity, Pintu;Kundu, Debasish;Ghosh, Tubai;Ranu, Brindaban C.. And the article was included in Organic Chemistry Frontiers in 2018.SDS of cas: 5460-32-2 This article mentions the following:

A new approach for the synthesis of aryl cyanides through C=C cleavage of styrenyl gem-dibromide via an in situ cyanation process by sodium azide in the presence of CuO nanoparticles and simultaneous intermol. cyanation of an iodoarene by capturing a released CN unit has been achieved. Several diversely substituted aryl/heteroaryl cyanides including a precursor to etravirine, a drug for the treatment of HIV, have been obtained by this procedure. This protocol is unique with regard to cyanation without a cyanide reagent and provides access to two different nitriles in one reaction involving full utilization of CN units. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gu, Wenxin et al. published their research in Organic Letters in 2003 | CAS: 2314-37-6

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 2314-37-6

New stable backbone linker resins for solid-phase peptide synthesis was written by Gu, Wenxin;Silverman, Richard B.. And the article was included in Organic Letters in 2003.Recommanded Product: 2314-37-6 This article mentions the following:

Two new 4-methoxybenzaldehyde backbone linker resins were developed for the solid-phase synthesis of peptides. The linkers are very stable during the cleavage of common protecting groups for amines (Fmoc, Boc) and carboxylic acids (Me, All, t-Bu) in peptide synthesis. Cleavage from the resin with refluxing TFA is sufficiently mild for peptides containing polar and nonpolar amino acids. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Recommanded Product: 2314-37-6).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 2314-37-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zheng, Limeng et al. published their research in Organic Letters in 2020 | CAS: 36748-88-6

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 36748-88-6

Tertiary Amines Acting as Alkyl Radical Equivalents Enabled by a P/N Heteroleptic Cu(I) Photosensitizer was written by Zheng, Limeng;Jiang, Qinfang;Bao, Hanyang;Zhou, Bingwei;Luo, Shu-Ping;Jin, Hongwei;Wu, Huayue;Liu, Yunkui. And the article was included in Organic Letters in 2020.SDS of cas: 36748-88-6 This article mentions the following:

An unprecedented exploration of tertiary amines as alkyl radical equivalent for cross-coupling with aromatic alkynes to access allylarenes has been achieved by a P/N heteroleptic Cu(I)-based photosensitizer under photoredox catalysis conditions. Mechanistic studies reveal that the reaction might undergo radical addition of in situ-generated 浼?amino radical intermediates to alkynes followed by 1,5-hydrogen transfer, C-N bond cleavage, and concomitant isomerization of the resulting allyl radical species. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6SDS of cas: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mehta, Saurabh et al. published their research in Journal of Organic Chemistry in 2010 | CAS: 36748-88-6

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 3-Iodobenzo[b]thiophene

Iodine/palladium approaches to the synthesis of polyheterocyclic compounds was written by Mehta, Saurabh;Larock, Richard C.. And the article was included in Journal of Organic Chemistry in 2010.Application In Synthesis of 3-Iodobenzo[b]thiophene This article mentions the following:

A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I2 or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of linked and fused PHCs. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Application In Synthesis of 3-Iodobenzo[b]thiophene).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 3-Iodobenzo[b]thiophene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lejeune, R. et al. published their research in Journal de Pharmacie de Belgique in 1980 | CAS: 15366-65-1

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 5-Iodonicotinic acid

Study of mercaptopyridinecarboxylic acids. I. Synthesis of halo(methoxycarbonyl)-1-methylpyridinium salts was written by Lejeune, R.;Thunus, L.;Lapiere, C. L.. And the article was included in Journal de Pharmacie de Belgique in 1980.Name: 5-Iodonicotinic acid This article mentions the following:

The methiodides I were obtained in 42-6% yield by quaternizing the corresponding pyridines with MeI in the presence of HgCl2 at 90鎺?for 6 h. I were hydrolyzed to give 60-75% of the diacids. IIIV and some related compounds were prepared by quaternization either in the absence or presence of HgCl2. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Name: 5-Iodonicotinic acid).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 5-Iodonicotinic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miura, Masahiro et al. published their research in Journal of the Chemical Society in 1987 | CAS: 36748-88-6

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 36748-88-6

Carbonylation of aryl halides and vinyl bromides mediated by tetracarbonylcobalt anion was written by Miura, Masahiro;Akase, Fumiaki;Shinohara, Masato;Nomura, Masakatsu. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Recommanded Product: 36748-88-6 This article mentions the following:

The reaction of aryl halides with octacarbonyldicobalt in the presence of Me iodide and sodium hydroxide under phase-transfer conditions gave a mixture of aryl Me ketones and aromatic carboxylic acids. For example, 1-bromonaphthalene gave 54% 1-acetonaphthone and 20% 1-naphthoic acid. From vinyl bromides the corresponding carboxylic acids were obtained exclusively. Thus, Ph2C:CHBr gave 80% Ph2C:CHCO2H. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Recommanded Product: 36748-88-6).

3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 36748-88-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lucas-Hourani, Marianne et al. published their research in Journal of Medicinal Chemistry in 2015 | CAS: 15813-09-9

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 4,5-Diiodo-1H-imidazole

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) was written by Lucas-Hourani, Marianne;Munier-Lehmann, Helene;El Mazouni, Farah;Malmquist, Nicholas A.;Harpon, Jane;Coutant, Eloi P.;Guillou, Sandrine;Helynck, Olivier;Noel, Anne;Scherf, Artur;Phillips, Margaret A.;Tangy, Frederic;Vidalain, Pierre-Olivier;Janin, Yves L.. And the article was included in Journal of Medicinal Chemistry in 2015.Recommanded Product: 4,5-Diiodo-1H-imidazole This article mentions the following:

Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bearing analogs. As in our previous report, the structure-activity study of this series of human DHODH inhibitors was based on a phenotypic assay measuring measles virus replication. Among other inhibitors, this round of syntheses and biol. evaluation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine (I). Inhibition of DHODH by this compoundI was confirmed in an array of in vitro assays, including enzymic tests and cell-based assays for viral replication and cellular growth. I was found to be more active than the known inhibitors of DHODH, brequinar and teriflunomide, thus opening perspectives for its use as a tool or for the design of an original series of immunosuppressive agent. Moreover, because other series of inhibitors of human DHODH have been found to also affect Plasmodium falciparum DHODH, all the compounds were assayed for their effect on P. falciparum growth. However, the modest in vitro inhibition solely observed for two compounds did not correlate with their inhibition of P. falciparum DHODH. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com